Someone who struggles with symptoms related to schizophrenia, major depression and/or bipolar disorder may benefit from taking Seroquel, an atypical antipsychotic medication. As an atypical drug, Seroquel belongs to the second generation class of antipsychotic drugs, meaning it interacts with more than one type of brain neurotransmitter chemical, according to the Centre for Addiction and Mental Health.

Taking an antipsychotic medication for any length of time comes with a risk of experiencing withdrawal symptoms when stopping the drug. Withdrawal from Seroquel results from the drug’s ability to alter chemical processes in the brain.

The likelihood you’ll experience withdrawal from Seroquel can vary depending on your individual circumstances in terms of physical and mental health status, dosage amounts and overall length of time on the drug. While it is possible to endure withdrawal from Seroquel on one’s own, the discomfort that often results may makes it difficult to abstain from taking the drug.


withdrawal from seroquel

If you regularly use Seroquel you may experience withdrawal when you stop.

Seroquel’s chemical make-up is designed to reduce neurotransmitter chemical production in the brain. More specifically, Seroquel targets dopamine and serotonin chemical outputs. It does this by blocking the cell receptor sites that secrete these chemicals. These mechanisms account for the drug’s ability to alleviate symptoms associated with schizophrenia, bipolar disorder and depression.

Over time, these interactions have a lasting effect on the brain’s ability to regulate chemical processes and manage bodily functions. In the process, individual brain cells undergo a certain degree of damage as a result of Seroquel’s effects.

Once a person stops taking the brain, the brain is left to reestablish a state of chemical equilibrium. The longer a person remains on Seroquel the more impaired brain chemical processes become. In effect, withdrawal from Seroquel develops out of these circumstances.

Dosage Levels

Withdrawal from Seroquel will last as long as it takes for the brain to resume normal function. The dosage level a person takes can have a considerable influence on whether he or she experiences withdrawal as well as how severe withdrawal from Seroquel will be.

Seroquel tablets come in 25, 50, 100, 200, 300 and 400 milligram dosage amounts. In general, the higher the dosage level the more the drug alters the brain’s chemical processes. These effects become more so pronounced in cases where a person remains on Seroquel for years at a time.

Pre-Existing Conditions

People who have pre-existing conditions when starting out on Seroquel have an increased chance of experiencing withdrawal from Seroquel when discontinuing drug use. Pre-existing conditions may be medical or psychological in origin. In effect, any condition that weakens the brain and/or body’s overall health makes a person more vulnerable to the effects of Seroquel withdrawal.

Method Used

A person can discontinue Seroquel use in one of two ways: “cold turkey” and tapering. Stopping drug use altogether (cold turkey) poses the greatest risk of experiencing withdrawal from Seroquel.

Tapering off the drug entails gradually reducing dosage amounts over a period of time. By doing so the brain has a better chance of maintaining normal bodily functions as a person weans off the drug.

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Seroquel Addiction Support Hotlines

AL - (907) 268-4185IA - (712) 266-3564NV - (775) 473-9889SD - (605) 385-0105
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